陳志龍教授
陳志龍，二級(jí)教授、博士生導(dǎo)師、主任藥師。為第二軍醫(yī)大學(xué)藥學(xué)學(xué)士、醫(yī)學(xué)博士（藥學(xué)專業(yè)），曾先后在中科院上海有機(jī)化學(xué)研究所、澳大利亞Central Queensland University、英國(guó)The University of Liverpool進(jìn)行3次博士后研究。曾任第二軍醫(yī)大學(xué)防護(hù)醫(yī)學(xué)教研室主任、學(xué)科帶頭人?，F(xiàn)為東華大學(xué)生物與醫(yī)學(xué)工程學(xué)院生物醫(yī)藥研究組課題組長(zhǎng)，PI，藥物化學(xué)與藥理學(xué)教授，博士生導(dǎo)師。發(fā)表論文350余篇。出版英文專著2部、中文專著3部。申請(qǐng)國(guó)家發(fā)明專利90余項(xiàng)。培養(yǎng)博士后、博士與碩士研究生120余名。
研究方向:
1. 人工智能（AI）和計(jì)算機(jī)輔助（CADD）新藥研發(fā)；
2. 光敏新藥研發(fā)及光動(dòng)力療法的基礎(chǔ)與應(yīng)用研究（如抗腫瘤、抗鮮紅斑痣、抗類風(fēng)濕性關(guān)節(jié)炎、抗菌抗病毒作用等）；
3. 靶向藥物研究（如抗腫瘤靶向新藥研究；降壓新藥研究；葉酸、多肽、單克隆抗體等靶向分子導(dǎo)向的新藥研究）；
4. 多功能、多模態(tài)藥物納米靶向制劑研究；
5. 中藥與天然藥物研究；
6. 藥物代謝、藥理毒理學(xué)及臨床藥學(xué)研究;
7. 醫(yī)學(xué)成像試劑研究。
榮譽(yù)及獲獎(jiǎng)情況：
1. 第二軍醫(yī)大學(xué) “學(xué)習(xí)成才十佳先進(jìn)個(gè)人”；
2. 上海市“浦江人才”；
3. 南京市“創(chuàng)新創(chuàng)業(yè)人才”；
4. 上海市“優(yōu)秀學(xué)術(shù)技術(shù)帶頭人”；
5. 嘉興市“科技領(lǐng)軍人才”;
6. 主持項(xiàng)目“光敏新藥與試劑的研制及光動(dòng)力療法的基礎(chǔ)與應(yīng)用研究”獲上海市藥學(xué)科技二等獎(jiǎng)（2012年）;
7. 主持項(xiàng)目“光敏新藥與試劑的研制及光動(dòng)力療法的基礎(chǔ)與應(yīng)用研究”獲中國(guó)藥學(xué)科技三等獎(jiǎng)（2013年）;
8. 參與項(xiàng)目（第二負(fù)責(zé)人）“光動(dòng)力治療皮膚病關(guān)鍵技術(shù)創(chuàng)新及推廣應(yīng)用”獲中華醫(yī)學(xué)科技三等獎(jiǎng)（2017年）;
9. 主持，平湖市創(chuàng)新創(chuàng)業(yè)大賽一等獎(jiǎng)----光敏新藥與試劑及降壓新藥研究開發(fā)（2018年）。
近年來(lái)承擔(dān)的主要科研項(xiàng)目：
承擔(dān)各類項(xiàng)目90余項(xiàng)，其中主持50余項(xiàng)。如主持各類人才基金5項(xiàng)、國(guó)家自然科學(xué)基金7項(xiàng)、軍隊(duì)醫(yī)藥衛(wèi)生重大課題1項(xiàng)、上海市科委與教委重點(diǎn)項(xiàng)目7項(xiàng)、國(guó)際合作項(xiàng)目8項(xiàng)等。參與國(guó)家與國(guó)際重要課題6項(xiàng)，如國(guó)家新藥創(chuàng)制重大專項(xiàng)、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目等；指導(dǎo)團(tuán)隊(duì)成員獲國(guó)家自然基金5項(xiàng)、國(guó)家與上海市博士后基金11項(xiàng)、上海市科委重點(diǎn)項(xiàng)目8項(xiàng)等。部分課題如下：
1. 國(guó)家自然科學(xué)基金（編號(hào)：21372042；30973611；30271534；30070862；29872055；21977016；22361132541等）。
2. 上海市優(yōu)秀學(xué)術(shù)技術(shù)帶頭人人才計(jì)劃基金（編號(hào)：15XD1523400）。
3. 上海市浦江人才計(jì)劃基金（編號(hào)：06PJ14001）。
4. 上海市科委重大重點(diǎn)基金（編號(hào)：064319020; 10DZ0502300; 13431900700；14140903500；14431906200；15411960400；15431904100；17431902600；21430730100等）。
5. 科技部與上海市國(guó)際科技合作基金（編號(hào)：6-11、11BA1400700、13430722300、17430711900、17430741800、18430713000、20490740400、21430730100; 9-33等）。
6. 軍隊(duì)醫(yī)藥衛(wèi)生重大項(xiàng)目（編號(hào)01L054）。
7. 上海市教委重點(diǎn)項(xiàng)目基金（編號(hào)：10ZZ45）。
8. 教育部科技研究重點(diǎn)項(xiàng)目（編號(hào)：108146）。
近年來(lái)發(fā)表的代表性論著、專利：
論文：
1. Tao Xu, Igor Vladimirovich Reshetov, Evgeniy Altarovna Kogan, Zhi-Long Chen*, et al. Quaternary ammonium cations conjugated 5,15-diaryltetranaphtho [2,3] porphyrins as photosensitizers for photodynamic therapy.European Journal of Medicinal Chemistry, 2024, 267, 116228.(SCI, Q1, TOP期刊)
2. Tao Xu, Le Mi, Zhi-Long Chen*, et al. Design, synthesis, and evaluation of 5,15- diaryltetranaphtho [2,3] porphyrins as photosensitizers in real-time photodynamic therapy and photodiagnosis. European Journal of Medicinal Chemistry, 2024, 264, 115980. (SCI, Q1, TOP期刊)
3. Ning Cao, Zhi-Long Chen*, et al. Synthesis and photodynamic activity of novel thieno[3,2–b]thiophene fused BODIPYs with good bio-solubility and anti-aggregation effect. Bioorganic Chemistry, 2024, 143, 107097. (SCI, Q1, TOP期刊).
4. Ning Cao, Zhi-Long Chen*, et al. Synthesis and evaluation of novelmeso-substitutedphenyldithieno[3,2-b]thiophene-fused BODIPY derivatives as efficient photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2024, 264,116012. (SCI, Q1，TOP期刊)
5. Tabbisa Namulinda, Justus Kwetegyeka, Ivan Gumula, Yomen Atassi, Sami Karam, Zhi-Long Chen*, et al. pH-responsive Photinia glabra–zinc oxide–protoporphyrin IX nanoconjugates with enhanced cellular uptake for photodynamic therapy towards cancer cells. Nanomedicine, 2023, 19(2): 127-143. (SCI, Q1)
6. Tabbisa Namulinda, Zhi-Long Chen*, et al. Antibacterial and anticancer activities of green synthesized silver nanoparticles using Photinia glabra fruit extract. Nanomedicine, 2023, 18, (14): 987-1002. (SCI, Q1)
7. Jianbo Wu, Zhilong Chen, et al. The use of multidimensional nomial logistic model and structural equation model in the validation of the 14-item health-literacy scale in Chinese patients living with type 2 diabetes. Risk Management and Healthcare Policy, 2023, 16，1567-1579.（SCI, Q2）
8. Jianbo Wu, Zhilong Chen*, et al. Self-efficacy as moderator and mediator between medication beliefs and adherence in elderly patients with type 2 diabetes. Patient Preference and Adherence, 2023, 17, 217-226. (SCI, Q3)
9. Man?Yi Li, Zhi?Long Chen*, et al. The bromoporphyrins as promising anti-tumor photosensitizers in vitro. Photochemical & Photobiological Sciences, 2023, 22, 427-439. (SCI, Q2)
10. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new fluorinated pyropheophorbide-a derivatives for photodynamic therapy. Dyes and Pigments, 2022, 197, 109932.(SCI, Q1,TOP期刊)
11. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new pyropheophorbide-a derivatives for CAIX-targeted photodynamic therapy. Dyes and Pigments, 2022, 203,110328.(SCI, Q1, TOP期刊).
12. Man Yi Li, Zhi Long Chen*, et al, The biological activities of 5,15-diaryl-10,20-dihalogeno porphyrins for photodynamic therapy. Journal of Cancer Research and Clinical Oncology, 2022, 148, 2335-2346. (SCI, Q2)
13. Refilwe Matshitse, Zhi-Long Chen, Tebello Nyokong, et al. Photodynamic therapy characteristics of phthalocyanines in the presence of boron doped detonation nanodiamonds: Effect of symmetry and charge. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102705. （SCI, Q3 ）
14. Faiza Sajjad, Zhi-Long Chen*, et al. Incorporation of green emission polymer dots into pyropheophorbide-α enhance the PDT effect andbiocompatibility. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102562.（SCI, Q3）
15. Man-Yi Li, Ying-Hua Gao, Zhi-Long Chen*, et al. Synthesis and evaluation of novel fluorinated hematoporphyrin ether derivatives for photodynamic therapy. Bioorganic Chemistry, 2021, 107, 104528.(SCI, Q1,TOP期刊)
16. Faiza Sajjad, Zhi-Long Chen*, et al. Synthesis and invitro PDT evaluation of red emission polymer dots (R-CPDs) and pyropheophorbide-α conjugates. Scientific Reports. 2021, 11, 10013. (SCI, Q2)
17. Zhuo Wu, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities. Bioorganic Chemistry, 2020, 101, 104042.(SCI, Q1,TOP期刊)
18. Ying-Hua Gao, Zhi-Long Chen*. Synthesis and pharmacological evaluation of chlorin derivatives for photodynamic therapy of cholangiocarcinoma. European Journal of Medicinal Chemistry, 2020,189, 112049.(SCI, Q1,TOP期刊)
20. Ying-Hua Gao, Vanda Lovrekovi?, Zhi-Long Chen*, et al. The photodynamic activities of dimethyl 131-[2-(guanidinyl)ethylamino] chlorin e6 photosensitizers in A549 tumor. European Journal of Medicinal Chemistry, 2019, 177, 144-152. (SCI, Q1,TOP期刊)
21. Zhuo Wu, Yi-Jia Yan, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of AT1 receptor blockers derived from 6-substituted aminocarbonyl benzimidazoles. European Journal of Medicinal Chemistry, 2019,181,111553. (SCI, Q1,TOP期刊)
22. Wei Zhu, Ying-Hua Gao, Zhi-Long Chen*, et al.Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity. European Journal of Medicinal Chemistry, 2018, 160, 146-156. (SCI, Q1,TOP期刊)
23. Ping-Yong Liao, Zhi-Long Chen*, et al. Synthesis of 2-morpholinetetraphenylporphyrins and their photodynamic activities. Bioorganic Chemistry, 2017, 71: 299 - 304.(SCI, Q1,TOP期刊)
24. Li Wang, Wei Zhu, Zhi-Long Chen*, et al. Preparation of a chlorophyll derivative and investigation of its photodynamic activities against cholangiocarcinoma. Biomedicine & Pharmacotherapy. 2017, 92: 285-292. (SCI, Q1,TOP期刊)
著作：
1. Akmaral Kussayeva, Zhilong Chen, Davor Margeti?*，Synthesis of Pheophorbide a and Chlorin e6Photosentisizers, In：Photosensitizers and their Applications. Page 129-154. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York. July 27, 2022. ISBN: 978-1-68507-880-5.
2. Yi-Jia Yan, Danye Chen, Davor Margeti?*, Zhi-Long Chen*. Photosensitizers and their Applications in China. In: Photosensitizers and their Applications. Page 155-192. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York, July 27, 2022. ISBN: 978-1-68507-880-5.
3. Ronald N. Warrener, Davor Margetic, David A. Mann, Zhi-Long Chen, and Douglas N. Butler. Novel geometry polynorbornane scaffolds for chromophore linkage and spacing. Artificial Photosynthesis: From Basic to Industrial Application. Page 147-166. November 2005. Edited by Anthony F. Collings and Christa Critchley. Wiley-Verlag GmbH & Co. KgaA, Weinheim. ISBN: 3-527-31090-8.
4. 張黎明，陳志龍主編?！冻Ｒ姾Ｑ笊飩乐沃改稀罚诙娽t(yī)大學(xué)出版社，2002年。
5. 姜成華，陳志龍主譯。《防化醫(yī)學(xué)手冊(cè)》，第二軍醫(yī)大學(xué)出版社，2001年。
6. 蔡建明，張建敏，陳志龍主編。《“三防”救治手冊(cè)》，2001年10月。
專利：
申請(qǐng)國(guó)家發(fā)明專利90余項(xiàng)。
主要學(xué)術(shù)兼職：
為中國(guó)光學(xué)會(huì)激光醫(yī)學(xué)分會(huì)常務(wù)理事；上海藥學(xué)會(huì)理事；上海生化藥物專業(yè)委員會(huì)副主任委員；上海藥物化學(xué)專業(yè)委員會(huì)委員；上海藥學(xué)會(huì)產(chǎn)學(xué)研創(chuàng)新工作委員會(huì)委員；上海市藥學(xué)會(huì)醫(yī)院藥學(xué)專委會(huì)委員；上海藥理學(xué)會(huì)治療藥物監(jiān)測(cè)研究專委會(huì)委員；上海市抗癌協(xié)會(huì)腫瘤藥學(xué)專委會(huì)委員；上海市醫(yī)院協(xié)會(huì)臨床藥事管理專委會(huì)委員；上海市醫(yī)學(xué)會(huì)第六屆醫(yī)療事故鑒定專家?guī)斐蓡T；上海市醫(yī)學(xué)會(huì)第四屆預(yù)防接種異常反應(yīng)鑒定專家?guī)斐蓡T。
為國(guó)家科學(xué)技術(shù)獎(jiǎng)勵(lì)評(píng)審專家；科技部重大重點(diǎn)專項(xiàng)評(píng)審專家；國(guó)家自然科學(xué)基金評(píng)審專家；教育部計(jì)劃項(xiàng)目與博士點(diǎn)基金評(píng)審專家；上海市科委項(xiàng)目評(píng)審專家。
國(guó)際交流與合作：
與英國(guó)帝國(guó)理工學(xué)院（Imperial College of London, UK）利物浦大學(xué)（The University of Liverpool, UK）；愛爾蘭都柏林大學(xué)(University College Dublin, Ireland)；愛爾蘭皇家外科學(xué)院(Royal College of Surgeons in Ireland, Ireland)；美國(guó)新澤西立大學(xué)(Rutgers，The State University of New Jersey，US) ；澳大利亞中昆士蘭大學(xué)（Central Queensland University, Australia）；克羅地亞魯?shù)聽柌┧箍凭S奇研究所(Rudjer Bo?kovi? Institute, Croatia) 、俄羅斯科學(xué)院（Institute of Russian Academy of Sciences, Russia）、俄羅斯莫斯科國(guó)立第一醫(yī)科大學(xué)(The First Moscow State Medical University named after I. M. Sechenov, Russia),、南非羅德斯大學(xué)(Rhodes University, South Africa)、緬甸仰光大學(xué)(University of Yangon, Myanmar)等多所大學(xué)與研究所有合作關(guān)系。
其它：
1. 研究團(tuán)隊(duì): 團(tuán)隊(duì)成員30余名，含博士助手2名、化學(xué)與生物醫(yī)學(xué)博士后2名、博士碩士研究生二十余名、留學(xué)生6名。
2. 博士后招聘：招收藥學(xué)、化學(xué)、生物學(xué)、醫(yī)學(xué)、材料學(xué)等專業(yè)博士后。
3. 博士、碩士研究生招生：在化學(xué)、生物化學(xué)與分子生物學(xué)、生物與醫(yī)藥、生物醫(yī)學(xué)工程、材料學(xué)等專業(yè)的博士、碩士點(diǎn)，招收藥學(xué)、化學(xué)、生物學(xué)、醫(yī)學(xué)、材料學(xué)等專業(yè)背景研究生。
電話：021-67792654；E-mail：zhlchen@dhu.edu.cn; zlchen1967@qq.com
Prof. Zhi-Long Chen
Curriculum Vitae：
Zhi-Long Chen got his B.Sc. and Ph.D. of Medicinal Chemistry from Second Military Medical University in 1996. He once worked as postdoctoral fellow in Shanghai Institute of Organic Chemistry, Chinese Academy of Science (China); in Central Queensland University (Australia) and the University of Liverpool (England). Prof. Chen has published more than 350 papers and 5 academic books, applied more than 90 patents. His projects were supported by more than 90 grants from Chinese Government and Shanghai Governments. More than 20 products were prepared and used in factories.
Research interests:
1. The discovery of new drug based on artificial intelligence (AI) and computer-aided drug design (CADD).
2. The discovery and development of new photosensitizer drugs in photodynamic therapy, and photo-diagnosis to tumor, senile macular degeneration, actinic keratosis, port-wine stains, rheumatoid arthritis.
3. The discovery and development of new targeted drugs, including new anti-tumor drugs，new antihypertensive drugs and new molecular targeted drugs (folic acid, peptides, monoclonal antibodies, etc.).
4. The discovery of targeted nano drug delivery system with multi-function and multimodal effects.
5. The discovery of new drugs from natural products.
6. Studies on the pharmacology, toxicology, pharmacokinetics and mechanism of new drugs.
7. The discovery of new medical imaging agents.
Awards:
1. “Shanghai Pujiang Talents” in 2008 from Shanghai Science and Technology Bureau.
2. “Shanghai Outstanding Science and Technology Group Leader” in 2014 from Shanghai Science and Technology Bureau.
3. Zhi-Long Chen, Wen-Hui Chen, Yi-Jia Yan, etc. “Studies on the discovery of new photodynamic drugs and reagents, on the fundamental research and application of photodynamic therapy” got the awards from Shanghai Pharmacy Association in 2012.
4. Zhi-Long Chen, Wen-Hui Chen, Yi-Jia Yan, etc. “Studies on the discovery of new photodynamic drugs and reagents, on the fundamental research and application of photodynamic therapy” got the awards from Chinese Pharmacy Association in 2013.
5. Xiu-Li Wang, Zhi-Long Chen, Heng Gu, etc. “The key technic innovations and their application of photodynamic therapy in skin diseases” got the award from Chinese Medicine Association in 2017.
6. The first prize of “Innovation and Entrepreneurship Competition of Pinghu city” in 2018.
Main scientific research projects:
More than 90 projects were supported by Chinese central government and Shanghai city government and other city governments. Such as hosting 5 talent funds, 7 national natural science funds, 1 major military medical and health project, 7 key projects of the Shanghai Municipal Science and Education Commission, and 8 international cooperation projects. Some of the projects as follows:
1. Grants from National Natural Science Foundation of China (No. 21372042; 30973611; 30271534 ; 30070862; 29872055; 21977016; 22361132541,et al).
2. Grant from “Shanghai Outstanding Science and Technology Group Leader” programme，（No.15XD1523400）.
3. Grant from “Shanghai Pujiang Talent” programme（No. 06PJ14001）.
4. The key grants from Shanghai government (No. 064319020; 10DZ0502300; 13431900700; 14140903500; 14431906200; 15411960400; 15431904100; 17431902600; 21430730100, et al)
5. International collaboration grant from Ministry of Science and Technology of China, and Shanghai government(No. 6-11; 11BA1400700; 13430722300; 17430711900; 17430741800; 18430713000; 20490740400; 21430730100; 9-33, et al).
6. Major Military Medical and Health Project (No. 01L054).
7. Shanghai Education Commission Key Project Fund (No.: 10ZZ45).
8. Key Project of Science and Technology Research from the Ministry of Education of China (No. 108146).
Publications:
Papers:
1. Tao Xu, Igor Vladimirovich Reshetov, Evgeniy Altarovna Kogan, Zhi-Long Chen*, et al. Quaternary ammonium cations conjugated 5,15-diaryltetranaphtho [2,3] porphyrins as photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2024, 267, 116228.(SCI, Q1, TOP Journal)
2. Tao Xu, Le Mi, Zhi-Long Chen*, et al. Design, synthesis, and evaluation of 5,15- diaryltetranaphtho [2,3] porphyrins as photosensitizers in real-time photodynamic therapy and photodiagnosis. European Journal of Medicinal Chemistry, 2024, 264, 115980. (SCI, Q1, TOP Journal)
3. Ning Cao, Zhi-Long Chen*, et al. Synthesis and photodynamic activity of novel thieno[3,2–b]thiophene fused BODIPYs with good bio-solubility and anti-aggregation effect. Bioorganic Chemistry, 2024, 143, 107097. (SCI, Q1, TOP Journal).
4. Ning Cao, Zhi-Long Chen*, et al. Synthesis and evaluation of novelmeso-substitutedphenyldithieno[3,2-b]thiophene-fused BODIPY derivatives as efficient photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2024, 264,116012. (SCI, IF: 6.7, Q1，TOP Journal)
5. Tabbisa Namulinda, Justus Kwetegyeka, Ivan Gumula, Yomen Atassi, Sami Karam, Zhi-Long Chen*, et al. pH-responsive Photinia glabra–zinc oxide–protoporphyrin IX nanoconjugates with enhanced cellular uptake for photodynamic therapy towards cancer cells. Nanomedicine, 2023, 19(2): 127-143. (SCI, Q1)
6. Tabbisa Namulinda, Zhi-Long Chen*, et al. Antibacterial and anticancer activities of green synthesized silver nanoparticles using Photinia glabra fruit extract. Nanomedicine, 2023, 18, (14): 987-1002. (SCI,Q1)
7. Jianbo Wu, Zhilong Chen, Songbai Zheng, et al. The use of multidimensional nomial logistic model and structural equation model in the validation of the 14-item health-literacy scale in Chinese patients living with type 2 diabetes. Risk Management and Healthcare Policy, 2023, 16，1567-1579.（SCI,Q2）
8. Jianbo Wu, Zhilong Chen*, et al. Self-efficacy as moderator and mediator between medication beliefs and adherence in elderly patients with type 2 diabetes. Patient Preference and Adherence, 2023, 17, 217-226. (SCI, Q3)
9. Man?Yi Li, Zhi?Long Chen*, et al. The bromoporphyrins as promising anti-tumor photosensitizers in vitro. Photochemical & Photobiological Sciences, 2023, 22, 427-439. (SCI,Q2)
10. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new fluorinated pyropheophorbide-a derivatives for photodynamic therapy. Dyes and Pigments, 2022, 197, 109932.(SCI, Q1,TOP Journal)
11. Feng Wang, Zhi-Long Chen*, et al. Synthesis and evaluation of new pyropheophorbide-a derivatives for CAIX-targeted photodynamic therapy. Dyes and Pigments, 2022, 203,110328.(SCI, Q1, TOP Journal)
12. Man Yi Li, Zhi Long Chen*, et al, The biological activities of 5,15-diaryl-10,20-dihalogeno porphyrins for photodynamic therapy. Journal of Cancer Research and Clinical Oncology, 2022, 148, 2335-2346. (SCI, Q2)
13. Refilwe Matshitse, Zhi-Long Chen, Tebello Nyokong, et al. Photodynamic therapy characteristics of phthalocyanines in the presence of boron doped detonation nanodiamonds: Effect of symmetry and charge. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102705. （SCI, Q3 ）
14. Faiza Sajjad, Zhi-Long Chen*, et al. Incorporation of green emission polymer dots into pyropheophorbide-α enhance the PDT effect andbiocompatibility. Photodiagnosis and Photodynamic Therapy, 2022, 37, 102562.（SCI, Q3）
15. Man-Yi Li, Ying-Hua Gao, Zhi-Long Chen*, et al. Synthesis and evaluation of novel fluorinated hematoporphyrin ether derivatives for photodynamic therapy. Bioorganic Chemistry, 2021, 107, 104528.(SCI, Q1,TOP Journal)
16. Faiza Sajjad, Zhi-Long Chen*, et al. Synthesis and invitro PDT evaluation of red emission polymer dots (R-CPDs) and pyropheophorbide-α conjugates. Scientific Reports. 2021, 11, 10013. (SCI, Q2)
17. Zhuo Wu, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities. Bioorganic Chemistry, 2020, 101, 104042.(SCI, Q1,TOP Journal)
18. Ying-Hua Gao, Zhi-Long Chen*. Synthesis and pharmacological evaluation of chlorin derivatives for photodynamic therapy of cholangiocarcinoma. European Journal of Medicinal Chemistry, 2020,189, 112049.(SCI, Q1,TOP Journal)
19. Ying-Hua Gao, Zhi-Long Chen*, Synthesis and evaluation of novel chlorophyll a derivatives as potent photosensitizers for photodynamic therapy. European Journal of Medicinal Chemistry, 2020, 187, 111959.(SCI, Q1,TOP Journal)
20. Ying-Hua Gao, Vanda Lovrekovi?, Zhi-Long Chen*, et al. The photodynamic activities of dimethyl 131-[2-(guanidinyl)ethylamino] chlorin e6 photosensitizers in A549 tumor. European Journal of Medicinal Chemistry, 2019, 177, 144-152. (SCI, Q1,TOP Journal)
21. Zhuo Wu, Yi-Jia Yan, Zhi-Long Chen*, et al. Design, synthesis and biological evaluation of AT1 receptor blockers derived from 6-substituted aminocarbonyl benzimidazoles. European Journal of Medicinal Chemistry, 2019,181,111553. (SCI, Q1,TOP Journal)
22. Wei Zhu, Ying-Hua Gao, Zhi-Long Chen*, et al.Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity. European Journal of Medicinal Chemistry, 2018, 160, 146-156. (SCI, Q1,TOP Journal)
23. Ping-Yong Liao, Zhi-Long Chen*, et al. Synthesis of 2-morpholinetetraphenylporphyrins and their photodynamic activities. Bioorganic Chemistry, 2017, 71: 299 - 304.(SCI, Q1,TOP期刊)
24. Li Wang, Wei Zhu, Zhi-Long Chen*, et al. Preparation of a chlorophyll derivative and investigation of its photodynamic activities against cholangiocarcinoma. Biomedicine & Pharmacotherapy. 2017, 92: 285-292. (SCI, Q1,TOP Journal)
Books:
1. Akmaral Kussayeva, Zhilong Chen, Davor Margeti?*，Synthesis of Pheophorbide a and Chlorin e6Photosentisizers, In：Photosensitizers and their Applications. Page 129-154. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York. 2022. July 27, 2022. ISBN: 978-1-68507-880-5.
2. Yi-Jia Yan, Danye Chen, Davor Margeti?*, Zhi-Long Chen*. Photosensitizers and their Applications in China. In: Photosensitizers and their Applications. Page 155-192. Editors: Davor Margetic and Renjith Thomas. Published by Nova Science Publishers, Inc. New York. 2022. Publication Date: July 27, 2022. ISBN: 978-1-68507-880-5.
3. Ronald N. Warrener, Davor Margetic, David A. Mann, Zhi-Long Chen, and Douglas N. Butler. Novel Geometry Polynorbornane Scaffolds for Chromophore Linkage and Spacing. Artificial Photosynthesis: From Basic to Industrial Application. Page 147-166. November 2005. Edited by Anthony F. Collings and Christa Critchley. Copyright @ 2005 Wiley-Verlag GmbH & Co. KgaA, Weinheim. ISBN: 3-527-31090-8.
4. Li-Ming Zhang, Zhi-Long Chen as chief editor. Guidelines for the Prevention and Treatment of Common Marine Biological Injuries, Published by Second Military Medical University Publishers, 2002.
5. Cheng-Hua Jiang, Zhi-Long Chen as main translator. Handbook of Preventive Medicine, Published by Second Military Medical University Publishers, 2001.
6. Jian-Ming Cai, Jian-Min Zhang, and Zhi-Long Chen. Three Prevention and Treatment Manual, 2001.
Patents:
More than 90 national invention patents have been applied.
Academic part-time jobs:
Prof. Zhi-Long Chen serves as committee member of Shanghai Association of Medicinal Chemistry, Shanghai Association of Pharmacy; committee member of Chinese Association of Laser Medicine; committee member of Shanghai Hospital Pharmacy Association; committee member of Therapeutic Drug Monitoring Research Committee of Shanghai Pharmacological Society; Committee of Shanghai Anti-Cancer Association and Clinical Pharmacy Management Committee of Shanghai Hospital Association; the member of Expert Pool for Shanghai Medical Association; the member of Medical Accident Appraisal and Identification of Abnormal Reactions to Vaccination of Shanghai Medical Association. Expert in the evaluation of major key projects of the Ministry of Science and Technology; Expert in the evaluation of the National Natural Science Foundation of China; Expert in the evaluation of the Ministry of Education's Program and Doctoral Program Fund; Expert in project evaluation from the Shanghai Municipal Commission of Science and Technology.
International Collaboration:
We have collaborations with scholars from UK (Imperial college of London; The University of Liverpool), Ireland (University College Dublin; Royal College of Surgeons in Ireland), US (Rutgers, The State University of New Jersey), Australia(Central Queensland University), Croatia(Rudjer Bo?kovi? Institute), Russia (Institute of Russian Academy of Sciences;The First Moscow State Medical University named after I. M. Sechenov), South Africa (Rhodes University),Myanmar(University of Yangon), et al which were supported by grants from Chinese central government and Shanghai city government.
Others:
Team:
We have a team more than 30 persons, including 2 assistants of PhD, 2 postdoctors, 8 Ph.D students and 14 Master students, 5 international students, 7 technicians.
Labs:
We have more than 300 m2 organic chemistry labs and biological labs in the University and 300 m2 outside the University.
Position Opportunity:
We accept students to our group to finish their Master degree and Ph. D. Postdoctoral research fellows and visiting scholars are also welcome.
Connecting Information:
E-mail: zlchen1967@qq.com; zhlchen@dhu.edu.cn;
Phone: 0086-21-67792654;
Address：Room 4110，Building 4, 2999 North Songjiang Renmin Road, Songjiang District, Shanghai, China. Postcode: 201620
